Phosphorylation of three regulatory serines of Tob by Erk1 and Erk2 is required for Ras-mediated cell proliferation and transformation

tob is a member of an emerging family of genes with antiproliferative function. Tob is rapidly phosphorylated at Ser 152, Ser 154, and Ser 164 by Erk1 and Erk2 upon growth-factor stimulation. Oncogenic Ras-induced transformation and growth-factor-induced cell proliferation are efficiently suppressed...

Deskribapen osoa

Gorde:
Xehetasun bibliografikoak
Egile Nagusiak: Suzuki, Toru, K-Tsuzuku, Junko, Ajima, Rieko, Nakamura, Takahisa, Yoshida, Yutaka, Yamamoto, Tadashi
Formatua: Artigo
Hizkuntza:Inglês
Argitaratua: Cold Spring Harbor Laboratory Press 2002
Gaiak:
Research Paper
Sarrera elektronikoa:https://ncbi.nlm.nih.gov/pmc/articles/PMC186319/
https://ncbi.nlm.nih.gov/pubmed/12050114
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1101/gad.962802
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