Inhibitory effect of deferoxamine or macrophage activation on transformation of Paracoccidioides brasiliensis conidia ingested by macrophages: reversal by holotransferrin.

Conidia of P. brasiliensis ingested by murine macrophages at 37 degrees C showed enhanced transformation to yeast cells and further intracellular growth compared with conidia in culture medium alone. Treatment of macrophages with the iron chelator deferoxamine inhibited the intracellular conidium-to...

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Pubblicato in:	Infect Immun
Autori principali:	Cano, L E, Gomez, B, Brummer, E, Restrepo, A, Stevens, D A
Natura:	Artigo
Lingua:	Inglês
Pubblicazione:	American Society for Microbiology (ASM) 1994
Soggetti:	Research Article
Accesso online:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC186311/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/8132359/ https://ncbi.nlm.nih.govhttps://doi.org/10.1128/iai.62.4.1494-1496.1994
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