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Amino acids in pneumolysin important for hemolytic activity identified by random mutagenesis.

The structural gene of pneumolysin was randomly mutagenized. A screen, developed to identify mutants with reduced hemolytic activity, identified substitutions within the cysteine-containing region and also at residues toward the N terminus of the toxin. These are the first reported changes within th...

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Bibliografske podrobnosti
Main Authors: Hill, J, Andrew, P W, Mitchell, T J
Format: Artigo
Jezik:Inglês
Izdano: 1994
Teme:
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC186175/
https://ncbi.nlm.nih.gov/pubmed/8300240
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