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Urinary Recovery of N-Formimidoyl Thienamycin (MK0787) as Affected by Coadministration of N-Formimidoyl Thienamycin Dehydropeptidase Inhibitors

N-Formimidoyl thienamycin (MK0787) undergoes renal metabolism by a dipeptidase, dehydropeptidase I, located on the brush border of the proximal tubular cells. The effects of two inhibitors (MK-789 and MK-791) of dehydropeptidase I on the pharmacokinetics of N-formimidoyl thienamycin were studied in...

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Publicat a:Antimicrob Agents Chemother
Autors principals: Norrby, S. R., Alestig, K., Björnegård, B., Burman, L. Å., Ferber, F., Huber, J. L., Jones, K. H., Kahan, F. M., Kahan, J. S., Kropp, H., Meisinger, M. A. P., Sundelof, J. G.
Format: Artigo
Idioma:Inglês
Publicat: American Society for Microbiology (ASM) 1983
Matèries:
Pharmacology
Accés en línia:https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC186041/
https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/6573157/
https://ncbi.nlm.nih.govhttps://doi.org/10.1128/aac.23.2.300
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