Gene targeting in mice reveals a requirement for angiotensin in the development and maintenance of kidney morphology and growth factor regulation.

Elevated levels of endogenous angiotensin can cause hypertensive nephrosclerosis as a result of the potent vasopressor action of the peptide. We have produced by gene targeting mice homozygous for a null mutation in the angiotensinogen gene (Atg-1-). Postnatally, Atg-1- animals show a modest delay i...

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Detalhes bibliográficos

Publicado no:	J Clin Invest
Principais autores:	Niimura, F, Labosky, P A, Kakuchi, J, Okubo, S, Yoshida, H, Oikawa, T, Ichiki, T, Naftilan, A J, Fogo, A, Inagami, T
Formato:	Artigo
Idioma:	Inglês
Publicado em:	American Society for Clinical Investigation 1995
Assuntos:	Research Article
Acesso em linha:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC186006/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/8675666/ https://ncbi.nlm.nih.govhttps://doi.org/10.1172/JCI118366
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