Damage to type II collagen in aging and osteoarthritis starts at the articular surface, originates around chondrocytes, and extends into the cartilage with progressive degeneration.

Enhanced denaturation of type II collagen fibrils in femoral condylar cartilage in osteoarthritis (OA) has recently been quantitated immunochemically (Hollander, A.P., T.F. Heathfield, C. Webber, Y. Iwata, R. Bourne, C. Rorabeck, and A.R. Poole. 1994. J. Clin. Invest. 93:1722-1732). Using the same a...

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Detalhes bibliográficos

Publicado no:	J Clin Invest
Principais autores:	Hollander, A P, Pidoux, I, Reiner, A, Rorabeck, C, Bourne, R, Poole, A R
Formato:	Artigo
Idioma:	Inglês
Publicado em:	American Society for Clinical Investigation 1995
Assuntos:	Research Article
Acesso em linha:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC185997/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/8675657/ https://ncbi.nlm.nih.govhttps://doi.org/10.1172/JCI118357
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