Ablation of hippocampal neurogenesis impairs contextual fear conditioning and synaptic plasticity in the dentate gyrus

Although hippocampal neurogenesis has been described in many adult mammals, the functional impact of this process on physiology and behavior remains unclear. In the present study, we used two independent methods to ablate hippocampal neurogenesis and found that each procedure caused a limited behavi...

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Main Authors: Saxe, Michael D., Battaglia, Fortunato, Wang, Jing-Wen, Malleret, Gael, David, Denis J., Monckton, James E., Garcia, A. Denise R., Sofroniew, Michael V., Kandel, Eric R., Santarelli, Luca, Hen, René, Drew, Michael R.
Format: Artigo
Sprog:Inglês
Udgivet: National Academy of Sciences 2006
Fag:
Biological Sciences
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC1859958/
https://ncbi.nlm.nih.gov/pubmed/17088541
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.0607207103
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