A pivotal role for endogenous TGF-β-activated kinase-1 in the LKB1/AMP-activated protein kinase energy-sensor pathway

TGF-β-activated kinase-1 (TAK1), also known as MAPKK kinase-7 (MAP3K7), is a candidate effector of multiple circuits in cardiac biology and disease. Here, we show that inhibition of TAK1 in mice by a cardiac-specific dominant-negative mutation evokes electrophysiological and biochemical properties r...

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Detalhes bibliográficos
Main Authors: Xie, Min, Zhang, Dou, Dyck, Jason R. B., Li, Yi, Zhang, Hui, Morishima, Masae, Mann, Douglas L., Taffet, George E., Baldini, Antonio, Khoury, Dirar S., Schneider, Michael D.
Formato: Artigo
Idioma:Inglês
Publicado em: National Academy of Sciences 2006
Assuntos:
Biological Sciences
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC1859937/
https://ncbi.nlm.nih.gov/pubmed/17085580
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.0604708103
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