Common genetic variation in the promoter of the human apo CIII gene abolishes regulation by insulin and may contribute to hypertriglyceridemia.

Overexpression of plasma apolipoprotein CIII (apo CIII) causes hypertriglyceridemia in transgenic mice. A genetically variant form of the human apo CIII promoter, containing five single base pair changes, has been shown to be associated with severe hypertriglyceridemia in a patient population. In an...

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Bibliografiske detaljer

Udgivet i:	J Clin Invest
Principais autores:	Li, W W, Dammerman, M M, Smith, J D, Metzger, S, Breslow, J L, Leff, T
Format:	Artigo
Sprog:	Inglês
Udgivet:	American Society for Clinical Investigation 1995
Fag:	Research Article
Online adgang:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC185964/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/8675624/ https://ncbi.nlm.nih.govhttps://doi.org/10.1172/JCI118324
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