Acid extrusion is induced by osteoclast attachment to bone. Inhibition by alendronate and calcitonin.
Acid extrusion is essential for osteoclast (OC) activity. We examined Na+ and HCO3(-)-independent H+ extrusion in rat- and mouse OCs by measuring intracellular pH (pHi) changes, with the pHi indicator BCECF (biscarboxyethyl-5-(6) carboxyfluorescein) after H+ loading with an ammonium pulse. 90% of OC...
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| Udgivet i: | J Clin Invest |
|---|---|
| Principais autores: | , , |
| Format: | Artigo |
| Sprog: | Inglês |
| Udgivet: |
American Society for Clinical Investigation
1995
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| Fag: | |
| Online adgang: | https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC185878/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/7593614/ https://ncbi.nlm.nih.govhttps://doi.org/10.1172/JCI118283 |
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