Acid extrusion is induced by osteoclast attachment to bone. Inhibition by alendronate and calcitonin.

Acid extrusion is essential for osteoclast (OC) activity. We examined Na+ and HCO3(-)-independent H+ extrusion in rat- and mouse OCs by measuring intracellular pH (pHi) changes, with the pHi indicator BCECF (biscarboxyethyl-5-(6) carboxyfluorescein) after H+ loading with an ammonium pulse. 90% of OC...

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Detalhes bibliográficos

Publicado no:	J Clin Invest
Principais autores:	Zimolo, Z, Wesolowski, G, Rodan, G A
Formato:	Artigo
Idioma:	Inglês
Publicado em:	American Society for Clinical Investigation 1995
Assuntos:	Research Article
Acesso em linha:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC185878/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/7593614/ https://ncbi.nlm.nih.govhttps://doi.org/10.1172/JCI118283
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