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Spontaneous hepatocarcinogenesis in farnesoid X receptor-null mice
The farnesoid X receptor (FXR) controls the synthesis and transport of bile acids. Mice lacking expression of FXR, designated Fxr-null, have elevated levels of serum and hepatic bile acids and an increase in bile acid pool size. Surprisingly, at 12 months of age, male and female Fxr-null mice had a...
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| Hlavní autoři: | , , , , , |
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| Médium: | Artigo |
| Jazyk: | Inglês |
| Vydáno: |
2006
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| Témata: | |
| On-line přístup: | https://ncbi.nlm.nih.gov/pmc/articles/PMC1858639/ https://ncbi.nlm.nih.gov/pubmed/17183066 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/carcin/bgl249 |
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