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Spontaneous hepatocarcinogenesis in farnesoid X receptor-null mice

The farnesoid X receptor (FXR) controls the synthesis and transport of bile acids. Mice lacking expression of FXR, designated Fxr-null, have elevated levels of serum and hepatic bile acids and an increase in bile acid pool size. Surprisingly, at 12 months of age, male and female Fxr-null mice had a...

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Detalhes bibliográficos
Main Authors: Kim, Insook, Morimura, Keiichirou, Shah, Yatrik, Yang, Qian, Ward, Jerrold M., Gonzalez, Frank J.
Formato: Artigo
Idioma:Inglês
Publicado em: 2006
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC1858639/
https://ncbi.nlm.nih.gov/pubmed/17183066
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/carcin/bgl249
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