Simple epithelium keratins are required for maintenance of hepatocyte integrity.

Keratin 8 (K8)-deficient adult mice develop a severe disease of the gastrointestinal tract characterized mainly by colorectal hyperplasia and inflammation. Given that hepatocytes contain K8/K18 heteropolymers only, this animal model was used to assess the contribution of these simple epithelium kera...

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Bibliografiske detaljer
Main Authors: Loranger, A., Duclos, S., Grenier, A., Price, J., Wilson-Heiner, M., Baribault, H., Marceau, N.
Format: Artigo
Sprog:Inglês
Udgivet: 1997
Fag:
Research Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC1858351/
https://ncbi.nlm.nih.gov/pubmed/9403718
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