Phorbol esters induce death in MCF-7 breast cancer cells with altered expression of protein kinase C isoforms. Role for p53-independent induction of gadd-45 in initiating death.

Protein kinase C (PKC) modulates growth, differentiation and apoptosis in a cell-specific fashion. Overexpression of PKC-alpha in MCF-7 breast cancer cells (MCF-7-PKC-alpha cell) leads to expression of a more transformed phenotype. The response of MCF-7 and MCF-7-PKC-alpha cells to phorbol esters (T...

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Detalhes bibliográficos
Main Authors: de Vente, J E, Kukoly, C A, Bryant, W O, Posekany, K J, Chen, J, Fletcher, D J, Parker, P J, Pettit, G J, Lozano, G, Cook, P P
Formato: Artigo
Idioma:Inglês
Publicado em: 1995
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC185824/
https://ncbi.nlm.nih.gov/pubmed/7560079
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