Absence of the mdr1a P-Glycoprotein in mice affects tissue distribution and pharmacokinetics of dexamethasone, digoxin, and cyclosporin A.

We have previously shown that absence of the mouse mdr1a (also called mdr3) P-glycoprotein in mdr1a (-/-) "knockout" mice has a profound effect on the tissue distribution and elimination of vinblastine and ivermectin, and hence on the toxicity of these compounds. We show here that the mouse mdr1a an...

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Bibliografiske detaljer

Udgivet i:	J Clin Invest
Principais autores:	Schinkel, A H, Wagenaar, E, van Deemter, L, Mol, C A, Borst, P
Format:	Artigo
Sprog:	Inglês
Udgivet:	American Society for Clinical Investigation 1995
Fag:	Research Article
Online adgang:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC185805/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/7560060/ https://ncbi.nlm.nih.govhttps://doi.org/10.1172/JCI118214
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