The Association of a SNP Upstream of INSIG2 with Body Mass Index is Reproduced in Several but Not All Cohorts

A SNP upstream of the INSIG2 gene, rs7566605, was recently found to be associated with obesity as measured by body mass index (BMI) by Herbert and colleagues. The association between increased BMI and homozygosity for the minor allele was first observed in data from a genome-wide association scan of...

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Main Authors: Lyon, Helen N, Emilsson, Valur, Hinney, Anke, Heid, Iris M, Lasky-Su, Jessica, Zhu, Xiaofeng, Thorleifsson, Gudmar, Gunnarsdottir, Steinunn, Walters, G. Bragi, Thorsteinsdottir, Unnur, Kong, Augustine, Gulcher, Jeffrey, Nguyen, Thuy Trang, Scherag, André, Pfeufer, Arne, Meitinger, Thomas, Brönner, Günter, Rief, Winfried, Soto-Quiros, Manuel E, Avila, Lydiana, Klanderman, Barbara, Raby, Benjamin A, Silverman, Edwin K, Weiss, Scott T, Laird, Nan, Ding, Xiao, Groop, Leif, Tuomi, Tiinamaija, Isomaa, Bo, Bengtsson, Kristina, Butler, Johannah L, Cooper, Richard S, Fox, Caroline S, O'Donnell, Christopher J, Vollmert, Caren, Celedón, Juan C, Wichmann, H. Erich, Hebebrand, Johannes, Stefansson, Kari, Lange, Christoph, Hirschhorn, Joel N
Format: Artigo
Language:Inglês
Published: Public Library of Science 2007
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Research Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC1857727/
https://ncbi.nlm.nih.gov/pubmed/17465681
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pgen.0030061
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