Apolipoprotein E levels in cerebrospinal fluid and the effects of ABCA1 polymorphisms

BACKGROUND: Animal studies suggest that brain apolipoprotein E (apoE) levels influence amyloid-β (Aβ) deposition and thus risk for Alzheimer's disease (AD). We have previously demonstrated that deletion of the ATP-binding cassette A1 transporter (ABCA1) in mice causes dramatic reductions in bra...

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Main Authors: Wahrle, Suzanne E, Shah, Aarti R, Fagan, Anne M, Smemo, Scott, Kauwe, John SK, Grupe, Andrew, Hinrichs, Anthony, Mayo, Kevin, Jiang, Hong, Thal, Leon J, Goate, Alison M, Holtzman, David M
Format: Artigo
Language:Inglês
Published: BioMed Central 2007
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Research Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC1857699/
https://ncbi.nlm.nih.gov/pubmed/17430597
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/1750-1326-2-7
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