Cdc37 has distinct roles in protein kinase quality control that protect nascent chains from degradation and promote posttranslational maturation

Cdc37 is a molecular chaperone that functions with Hsp90 to promote protein kinase folding. Analysis of 65 Saccharomyces cerevisiae protein kinases (∼50% of the kinome) in a cdc37 mutant strain showed that 51 had decreased abundance compared with levels in the wild-type strain. Several lipid kinases...

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Main Authors: Mandal, Atin K., Lee, Paul, Chen, Jennifer A., Nillegoda, Nadinath, Heller, Alana, DiStasio, Susan, Oen, Handy, Victor, Jacob, Nair, Devi M., Brodsky, Jeffrey L., Caplan, Avrom J.
Format: Artigo
Sprog:Inglês
Udgivet: The Rockefeller University Press 2007
Fag:
Research Articles
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC1857360/
https://ncbi.nlm.nih.gov/pubmed/17242065
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1083/jcb.200604106
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