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Fluorous synthesis of disubstituted pyrimidines
The fluorous synthesis of disubstituted pyrimidines is carried out by attaching 2,4-dichloro-6-methylpyrimidine with 1H,1H,2H,2H-perfluorodecanethiol. The tagged substrate is substituted with 3-(trifluoromethyl)pyrazole followed by thioether oxidation and tag displacement with amines and thiols. The...
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| Main Author: | |
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| Format: | Artigo |
| Language: | Inglês |
| Published: |
2003
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| Subjects: | |
| Online Access: | https://ncbi.nlm.nih.gov/pmc/articles/PMC1857353/ https://ncbi.nlm.nih.gov/pubmed/12659561 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/ol027469e |
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