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The formation of peripheral myelin protein 22 aggregates is hindered by the enhancement of autophagy and expression of cytoplasmic chaperones

The accumulation of misfolded proteins is associated with various neurodegenerative conditions. Peripheral myelin protein 22 (PMP22) is a hereditary neuropathy-linked, short-lived molecule that forms aggresomes when the proteasome is inhibited or the protein is mutated. We previously showed that the...

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Detalhes bibliográficos
Main Authors: Fortun, Jenny, Verrier, Jonathan D., Go, Jocelyn C., Madorsky, Irina, Dunn, William A., Notterpek, Lucia
Formato: Artigo
Idioma:Inglês
Publicado em: 2006
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC1857308/
https://ncbi.nlm.nih.gov/pubmed/17174099
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.nbd.2006.09.018
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