Monitoring of plasmid-encoded, trimethoprim-resistant dihydrofolate reductase genes: detection of a new resistant enzyme.

Using-gene-specific radiolabeled probe DNAs, we analyzed 42 clinical bacterial isolates with high-level trimethoprim (Tp) resistance for the presence of a type I or a type II plasmid-specified dihydrofolate reductase (DHFR) gene. Plasmid DNA from 17 strains harbored a type I DHFR, whereas 11 isolate...

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Veröffentlicht in:	Antimicrob Agents Chemother
Hauptverfasser:	Fling, M E, Walton, L, Elwell, L P
Format:	Artigo
Sprache:	Inglês
Veröffentlicht:	American Society for Microbiology (ASM) 1982
Schlagworte:	Research Article
Online-Zugang:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC185675/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/7181492/ https://ncbi.nlm.nih.govhttps://doi.org/10.1128/aac.22.5.882
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