Role of serum protein binding and multiple antibiotic doses in the extravascular distribution of ceftizoxime and cefotaxime.

The extravascular penetration of ceftizoxime and cefotaxime was studied in a rabbit subcutaneous Visking chamber model. Four rabbits, implanted with four chambers each, received each drug intramuscularly at a dose of 50 mg/kg every 3 hours for eight doses. Serum drug concentrations were measured aft...

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Veröffentlicht in:	Antimicrob Agents Chemother
Hauptverfasser:	Gerding, D N, Van Etta, L L, Peterson, L R
Format:	Artigo
Sprache:	Inglês
Veröffentlicht:	American Society for Microbiology (ASM) 1982
Schlagworte:	Research Article
Online-Zugang:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC185670/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/6295269/ https://ncbi.nlm.nih.govhttps://doi.org/10.1128/aac.22.5.844
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