Changes in expression and distribution of claudin 2, 5 and 8 lead to discontinuous tight junctions and barrier dysfunction in active Crohn's disease

BACKGROUND: Epithelial barrier function is impaired in Crohn's disease. AIM: To define the underlying cellular mechanisms with special attention to tight junctions. METHODS: Biopsy specimens from the sigmoid colon of patients with mild to moderately active or inactive Crohn's disease were...

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Hlavní autoři: Zeissig, S, Bürgel, N, Günzel, D, Richter, J, Mankertz, J, Wahnschaffe, U, Kroesen, A J, Zeitz, M, Fromm, M, Schulzke, J‐D
Médium: Artigo
Jazyk:Inglês
Vydáno: BMJ Group 2007
Témata:
Inflammatory Bowel Disease
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC1856677/
https://ncbi.nlm.nih.gov/pubmed/16822808
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1136/gut.2006.094375
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