Tumour necrosis factor α signalling through activation of Kupffer cells plays an essential role in liver fibrosis of non‐alcoholic steatohepatitis in mice

BACKGROUND: While tumour necrosis factor α (TNF‐α) appears to be associated with the development of non‐alcoholic steatohepatitis (NASH), its precise role in the pathogenesis of NASH is not well understood. METHODS: Male mice deficient in both TNF receptors 1 (TNFR1) and 2 (TNFR2) (TNFRDKO mice) and...

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Autori principali: Tomita, K, Tamiya, G, Ando, S, Ohsumi, K, Chiyo, T, Mizutani, A, Kitamura, N, Toda, K, Kaneko, T, Horie, Y, Han, J‐Y, Kato, S, Shimoda, M, Oike, Y, Tomizawa, M, Makino, S, Ohkura, T, Saito, H, Kumagai, N, Nagata, H, Ishii, H, Hibi, T
Natura: Artigo
Lingua:Inglês
Pubblicazione: BMJ Group 2006
Soggetti:
Liver Fibrosis
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC1856073/
https://ncbi.nlm.nih.gov/pubmed/16174657
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1136/gut.2005.071118
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