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Defective Ribonucleoside Diphosphate Reductase Impairs Replication Fork Progression in Escherichia coli

The observed lengthening of the C period in the presence of a defective ribonucleoside diphosphate reductase has been assumed to be due solely to the low deoxyribonucleotide supply in the nrdA101 mutant strain. We show here that the nrdA101 mutation induces DNA double-strand breaks at the permissive...

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Autores principales: Guarino, Estrella, Jiménez-Sánchez, Alfonso, Guzmán, Elena C.
Formato: Artigo
Lenguaje:Inglês
Publicado: American Society for Microbiology 2007
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Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC1855873/
https://ncbi.nlm.nih.gov/pubmed/17322311
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/JB.01632-06
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