Roxithromycin Favorably Modifies the Initial Phase of Resistance against Infection with Macrolide-Resistant Streptococcus pneumoniae in a Murine Pneumonia Model

Sub-MIC levels of macrolides down-regulate bacterial virulence factors and suppress inflammatory processes. The ability of macrolides to reduce the production of pneumolysin has been shown to explain the discrepancy between in vitro resistance and outcomes with macrolides against macrolide-resistant...

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Autors principals: Yasuda, Yasuki, Kasahara, Kei, Mizuno, Fumiko, Nishi, Kazuyuki, Mikasa, Keiichi, Kita, Eiji
Format: Artigo
Idioma:Inglês
Publicat: American Society for Microbiology (ASM) 2007
Matèries:
Experimental Therapeutics
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC1855574/
https://ncbi.nlm.nih.gov/pubmed/17353244
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/AAC.01459-06
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