Role of group-conserved residues in the helical core of β(2)-adrenergic receptor

G protein-coupled receptors (GPCRs) belonging to class A contain several highly conserved (>90%) amino acids in their transmembrane helices. Results of mutational studies of these highly conserved residues suggest a common mechanism for locking GPCRs in an inactive conformation and for their subs...

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Autori principali: Chelikani, Prashen, Hornak, Viktor, Eilers, Markus, Reeves, Phillip J., Smith, Steven O., RajBhandary, Uttam L., Khorana, H. Gobind
Natura: Artigo
Lingua:Inglês
Pubblicazione: National Academy of Sciences 2007
Soggetti:
Biological Sciences
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC1855394/
https://ncbi.nlm.nih.gov/pubmed/17438264
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.0702024104
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