The transcription factor HIF-1α plays a critical role in the growth factor-dependent regulation of both aerobic and anaerobic glycolysis

Mammalian cells are believed to have a cell-intrinsic ability to increase glucose metabolism in response to hypoxia. Here we show that the ability of hematopoietic cells to up-regulate anaerobic glycolysis in response to hypoxia is dependent on receptor-mediated signal transduction. In the absence o...

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Bibliografiske detaljer
Main Authors: Lum, Julian J., Bui, Thi, Gruber, Michaela, Gordan, John D., DeBerardinis, Ralph J., Covello, Kelly L., Simon, M. Celeste, Thompson, Craig B.
Format: Artigo
Sprog:Inglês
Udgivet: Cold Spring Harbor Laboratory Press 2007
Fag:
Research Paper
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC1855230/
https://ncbi.nlm.nih.gov/pubmed/17437992
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1101/gad.1529107
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