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Visualizing the ATPase Cycle in a Protein Disaggregating Machine: Structural Basis for Substrate Binding by ClpB

ClpB is a ring-shaped molecular chaperone, which has the remarkable ability to disaggregate stress-damaged proteins. Here we present the electron cryomicroscopy reconstruction of an ATP-activated ClpB trap mutant, along with reconstructions of ClpB in the AMPPNP, ADP, and in the nucleotide-free stat...

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Detaylı Bibliyografya
Asıl Yazarlar: Lee, Sukyeong, Choi, Jae-Mun, Tsai, Francis T.F.
Materyal Türü: Artigo
Dil:Inglês
Baskı/Yayın Bilgisi: 2007
Konular:
Online Erişim:https://ncbi.nlm.nih.gov/pmc/articles/PMC1855157/
https://ncbi.nlm.nih.gov/pubmed/17244533
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.molcel.2007.01.002
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