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A Conditional Yeast E1 Mutant Blocks the Ubiquitin–Proteasome Pathway and Reveals a Role for Ubiquitin Conjugates in Targeting Rad23 to the Proteasome

E1 ubiquitin activating enzyme catalyzes the initial step in all ubiquitin-dependent processes. We report the isolation of uba1-204, a temperature-sensitive allele of the essential Saccharomyces cerevisiae E1 gene, UBA1. Uba1-204 cells exhibit dramatic inhibition of the ubiquitin–proteasome system,...

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Detalhes bibliográficos
Main Authors: Ghaboosi, Nazli, Deshaies, Raymond J.
Formato: Artigo
Idioma:Inglês
Publicado em: The American Society for Cell Biology 2007
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC1855034/
https://ncbi.nlm.nih.gov/pubmed/17360968
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1091/mbc.E06-10-0965
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