Claudin-4 Overexpression in Epithelial Ovarian Cancer Is Associated with Hypomethylation and Is a Potential Target for Modulation of Tight Junction Barrier Function Using a C-Terminal Fragment of Clostridium perfringens Enterotoxin

BACKGROUND: Claudin-4, a tight junction (TJ) protein and receptor for the C-terminal fragment of Clostridium perfringens enterotoxin (C-CPE), is overexpressed in epithelial ovarian cancer (EOC). Previous research suggests DNA methylation is a mechanism for claudin-4 overexpression in cancer and that...

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Autors principals: Litkouhi, Babak, Kwong, Joseph, Lo, Chun-Min, Smedley, James G, McClane, Bruce A, Aponte, Margarita, Gao, Zhijian, Sarno, Jennifer L, Hinners, Jennifer, Welch, William R, Berkowitz, Ross S, Mok, Samuel C, Garner, Elizabeth I O
Format: Artigo
Idioma:Inglês
Publicat: Neoplasia Press Inc. 2007
Matèries:
Research Article
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC1854850/
https://ncbi.nlm.nih.gov/pubmed/17460774
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