A phage integrase directs efficient site-specific integration in human cells

The integrase from the Streptomyces phage φC31 carries out efficient recombination between the attP site in the phage genome and the attB site in the host bacterial chromosome. In this paper, we show that the enzyme also functions in human cells. A plasmid assay system was constructed that measured...

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Dades bibliogràfiques

Publicat a:	Proc Natl Acad Sci U S A
Autors principals:	Groth, Amy C., Olivares, Eric C., Thyagarajan, Bhaskar, Calos, Michele P.
Format:	Artigo
Idioma:	Inglês
Publicat:	National Academy of Sciences 2000
Matèries:	Biological Sciences
Accés en línia:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC18547/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/10801973/ https://ncbi.nlm.nih.govhttps://doi.org/10.1073/pnas.090527097
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