Alpha 1-adrenoceptor antagonist activity of novel pyrimidine derivatives (SHI437 and IK29) in rabbit aorta and trigone of the bladder.

1. In the rabbit isolated aorta and trigone of the bladder, noradrenaline, phenylephrine and clonidine elicited concentration-dependent contractions, which may be caused through activation of postsynaptic alpha 1-adrenoceptors. 2. SHI437, IK29, prazosin and yohimbine competitively antagonized the co...

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Autors principals: Azuma, H., Sugimoto-Tokushima, M., Tanaka, K., Ikenoue, Y., Ito, S., Ishikawa, M.
Format: Artigo
Idioma:Inglês
Publicat: 1989
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Research Article
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC1854419/
https://ncbi.nlm.nih.gov/pubmed/2568139
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