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Efficacy of the acyclic nucleoside 9-(1,3-dihydroxy-2-propoxymethyl)guanine against primary and recrudescent genital herpes simplex virus type 2 infections in guinea pigs.

The acyclic nucleoside 9-(1,3-dihydroxy-2-propoxymethyl)guanine (DHPG) was evaluated for its efficacy in protecting guinea pigs from primary and recrudescent infections of herpes simplex virus type 2. Vaginally infected guinea pigs were treated twice a day with DHPG at 25 mg/kg per dose for 3 weeks....

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Detalhes bibliográficos
Publicado no:Antimicrob Agents Chemother
Principais autores: Fraser-Smith, E B, Smee, D F, Matthews, T R
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Microbiology (ASM) 1983
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC185401/
https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/6607031/
https://ncbi.nlm.nih.govhttps://doi.org/10.1128/aac.24.6.883
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