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Tumor Formation via Loss of a Molecular Motor Protein

Aneuploidy has long been suggested to be causal in tumor formation. Direct testing of this hypothesis has been difficult because of the absence of methods to specifically induce aneuploidy. The chromosome associated kinesin motor KIF4 plays multiple roles in mitosis, and its loss leads to multiple m...

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Autori principali: Mazumdar, Manjari, Lee, Ji-Hyeon, Sengupta, Kundan, Ried, Thomas, Rane, Sushil, Misteli, Tom
Natura: Artigo
Lingua:Inglês
Pubblicazione: 2006
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Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC1853379/
https://ncbi.nlm.nih.gov/pubmed/16890532
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.cub.2006.06.029
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