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Lithium Regulates Glycogen Synthase Kinase-3β in Human Peripheral Blood Mononuclear Cells: Implication in the Treatment of Bipolar Disorder

BACKGROUND: Bipolar disorder has been linked to alterations in the multifunctional enzyme glycogen synthase kinase-3β (GSK3β). The mood stabilizer lithium inhibits GSK3β in vitro and in mouse brain, and this is currently the strongest known potential therapeutic target of lithium. We tested whether...

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Bibliografiset tiedot
Päätekijät: Li, Xiaohua, Friedman, Ari B., Zhu, Wawa, Wang, Li, Boswell, Sherer, May, Roberta S., Davis, Lori L., Jope, Richard S.
Aineistotyyppi: Artigo
Kieli:Inglês
Julkaistu: 2006
Aiheet:
Linkit:https://ncbi.nlm.nih.gov/pmc/articles/PMC1853347/
https://ncbi.nlm.nih.gov/pubmed/16806104
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.biopsych.2006.02.027
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