HISTONE H3-K56 ACETYLATION IS CATALYZED BY HISTONE CHAPERONE-DEPENDENT COMPLEXES

Acetylation of histone H3 on lysine 56 occurs during mitotic and meiotic S phase in fungal species. This acetylation blocks a direct electrostatic interaction between histone H3 and nucleosomal DNA, and the absence of this modification is associated with extreme sensitivity to genotoxic agents. We s...

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Main Authors: Tsubota, Toshiaki, Berndsen, Christopher E., Erkmann, Judith A., Smith, Corey L., Yang, Lanhao, Freitas, Michael A., Denu, John M., Kaufman, Paul D.
Format: Artigo
Sprog:Inglês
Udgivet: 2007
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Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC1853276/
https://ncbi.nlm.nih.gov/pubmed/17320445
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.molcel.2007.02.006
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