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Nuclear clusterin/XIP8, an x-ray-induced Ku70-binding protein that signals cell death

Clusterin [CLU, a.k.a. TRPM-2, SGP-2, or ionizing radiation (IR)-induced protein-8 (XIP8)] was implicated in apoptosis, tissue injury, and aging. Its function remains elusive. We reisolated CLU/XIP8 by yeast two-hybrid analyses using as bait the DNA double-strand break repair protein Ku70. We show t...

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Bibliografiske detaljer
Main Authors: Yang, Chin-Rang, Leskov, Konstantin, Hosley-Eberlein, Kelly, Criswell, Tracy, Pink, John J., Kinsella, Timothy J., Boothman, David A.
Format: Artigo
Sprog:Inglês
Udgivet: The National Academy of Sciences 2000
Fag:
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC18532/
https://ncbi.nlm.nih.gov/pubmed/10823943
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