Tracing Cell Fates in Human Colorectal Tumors from Somatic Microsatellite Mutations : Evidence of Adenomas with Stem Cell Architecture

Occult aspects of tumor proliferation are likely recorded genetically as their microsatellite (MS) loci become polymorphic. However, MS mutations generated by division may also be eliminated with death as noncoding MS loci lack selective value. Therefore, highly polymorphic MS loci cannot exist unle...

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Autors principals: Tsao, Jen-Lan, Zhang, Jingsong, Salovaara, Reijo, Li, Zhi-Hua, Järvinen, Heikki J., Mecklin, Jukka-Pekka, Aaltonen, Lauri A., Shibata, Darryl
Format: Artigo
Idioma:Inglês
Publicat: American Society for Investigative Pathology 1998
Matèries:
Regular Articles
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC1853055/
https://ncbi.nlm.nih.gov/pubmed/9777950
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