Transcriptional induction of prostaglandin G/H synthase-2 by basic fibroblast growth factor.

In serum-free mouse osteoblastic MC3T3-E1 cells, basic fibroblastic growth factor (bFGF) induced mRNA and protein for prostaglandin G/H synthase-2 (PGHS-2), the major enzyme in arachidonic acid (AA) conversion to prostaglandins. mRNA accumulation peaked at 1 h with bFGF 1 nM. In cells stably transfe...

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Main Authors: Kawaguchi, H, Pilbeam, C C, Gronowicz, G, Abreu, C, Fletcher, B S, Herschman, H R, Raisz, L G, Hurley, M M
Format: Artigo
Jezik:Inglês
Izdano: 1995
Teme:
Research Article
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC185280/
https://ncbi.nlm.nih.gov/pubmed/7635987
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