Rapid activation of CLOCK by Ca(2+)-dependent protein kinase C mediates resetting of the mammalian circadian clock

In mammals, immediate-early transcription of the Period 1 (Per1) gene is crucial for resetting the mammalian circadian clock. Here, we show that CLOCK is a real signalling molecule that mediates the serum-evoked rapid induction of Per1 in fibroblasts through the Ca(2+)-dependent protein kinase C (PK...

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Detalhes bibliográficos
Main Authors: Shim, Hong Seok, Kim, Hyunjung, Lee, Jiwon, Son, Gi Hoon, Cho, Sehyung, Oh, Tae H, Kang, Sang Hyeon, Seen, Dong-Seung, Lee, Kun Ho, Kim, Kyungjin
Formato: Artigo
Idioma:Inglês
Publicado em: 2007
Assuntos:
Scientific Report
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC1852771/
https://ncbi.nlm.nih.gov/pubmed/17347670
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/sj.embor.7400920
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