Somatic mutation and CDR3 lengths of immunoglobulin kappa light chains expressed in patients with rheumatoid arthritis and in normal individuals.

Immunoglobulin secretion by plasma cells infiltrating synovial membranes is a prominent feature of RA. Previous analyses of a cDNA library generated from synovium of RA patient BC revealed immunoglobulin kappa light chain transcripts with extensive somatic mutation, frequent N region addition, and u...

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Detalles Bibliográficos

Publicado en:	J Clin Invest
Principais autores:	Bridges, S L, Lee, S K, Johnson, M L, Lavelle, J C, Fowler, P G, Koopman, W J, Schroeder, H W
Formato:	Artigo
Idioma:	Inglês
Publicado:	American Society for Clinical Investigation 1995
Assuntos:	Research Article
Acceso en liña:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC185269/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/7635977/ https://ncbi.nlm.nih.govhttps://doi.org/10.1172/JCI118129
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