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Loss of apolipoprotein E exacerbates the neonatal lethality of the Smith-Lemli-Opitz syndrome mouse

The Smith-Lemli-Opitz syndrome (SLOS) is caused by a genetic defect in cholesterol biosynthesis; mutations in the enzyme 3ß-hydroxysterol Δ7 reductase (Dhcr7) lead to a failure of cholesterol (and desmosterol) synthesis, with an accumulation of precursor sterols, such as 7-dehydrocholesterol. Extens...

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Detalhes bibliográficos
Main Authors: Solcà, Curzio, Pandit, Bhaswati, Yu, Hongwei, Tint, G. Stephen, Patel, Shailendra B.
Formato: Artigo
Idioma:Inglês
Publicado em: 2007
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC1852500/
https://ncbi.nlm.nih.gov/pubmed/17197219
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.ymgme.2006.11.009
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