Hemolysis in sickle cell mice causes pulmonary hypertension due to global impairment in nitric oxide bioavailability

Pulmonary hypertension is a highly prevalent complication of sickle cell disease and is a strong risk factor for early mortality. However, the pathophysiologic mechanisms leading to pulmonary vasculopathy remain unclear. Transgenic mice provide opportunities for mechanistic studies of vascular patho...

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Bibliografiska uppgifter
Huvudupphovsmän: Hsu, Lewis L., Champion, Hunter C., Campbell-Lee, Sally A., Bivalacqua, Trinity J., Manci, Elizabeth A., Diwan, Bhalchandra A., Schimel, Daniel M., Cochard, Audrey E., Wang, Xunde, Schechter, Alan N., Noguchi, Constance T., Gladwin, Mark T.
Materialtyp: Artigo
Språk:Inglês
Publicerad: American Society of Hematology 2007
Ämnen:
Red Cells
Länkar:https://ncbi.nlm.nih.gov/pmc/articles/PMC1852224/
https://ncbi.nlm.nih.gov/pubmed/17158223
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1182/blood-2006-08-039438
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