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The Lactoperoxidase System Links Anion Transport To Host Defense in Cystic Fibrosis

Chronic respiratory infections in cystic fibrosis result from CFTR channel mutations but how these impair antibacterial defense is less clear. Airway host defense depends on lactoperoxidase (LPO) that requires thiocyanate (SCN(−)) to function and epithelia use CFTR to concentrate SCN(−) at the apica...

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Main Authors: Conner, Gregory E., Wijkstrom-Frei, Corinne, Randell, Scott H., Fernandez, Vania E., Salathe, Matthias
格式: Artigo
語言:Inglês
出版: 2006
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在線閱讀:https://ncbi.nlm.nih.gov/pmc/articles/PMC1851694/
https://ncbi.nlm.nih.gov/pubmed/17204267
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.febslet.2006.12.025
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