Folding of an MHC class II-restricted tumor antigen controls its antigenicity via MHC-guided processing

CD4(+) and CD8(+) T cell responses to endogenous retroviral envelope glycoprotein gp90 generate protective immunity to murine colon carcinoma CT26. A panel of I-A(d)-restricted T cell hybridomas recognize gp90 synthesized by CT26 cells but not by other gp90-expressing tumors. Here we report that ant...

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Autores principales: Mimura, Yusuke, Mimura-Kimura, Yuka, Doores, Katie, Golgher, Denise, Davis, Benjamin G., Dwek, Raymond A., Rudd, Pauline M., Elliott, Tim
Formato: Artigo
Lenguaje:Inglês
Publicado: National Academy of Sciences 2007
Materias:
Biological Sciences
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC1851603/
https://ncbi.nlm.nih.gov/pubmed/17389359
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.0701307104
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