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Destruction of long-range interactions by a single mutation in lysozyme
We propose a mechanism, based on a ≥10-μs molecular dynamics simulation, for the surprising misfolding of hen egg-white lysozyme caused by a single mutation (W62G). Our simulations of the wild-type and mutant lysozymes in 8 M urea solution at biological temperature (with both pH 2 and 7) reveal that...
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| Main Authors: | , , , |
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| Format: | Artigo |
| Jezik: | Inglês |
| Izdano: |
National Academy of Sciences
2007
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| Teme: | |
| Online dostop: | https://ncbi.nlm.nih.gov/pmc/articles/PMC1851576/ https://ncbi.nlm.nih.gov/pubmed/17389393 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.0701249104 |
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