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Destruction of long-range interactions by a single mutation in lysozyme

We propose a mechanism, based on a ≥10-μs molecular dynamics simulation, for the surprising misfolding of hen egg-white lysozyme caused by a single mutation (W62G). Our simulations of the wild-type and mutant lysozymes in 8 M urea solution at biological temperature (with both pH 2 and 7) reveal that...

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Detaylı Bibliyografya
Asıl Yazarlar: Zhou, Ruhong, Eleftheriou, Maria, Royyuru, Ajay K., Berne, Bruce J.
Materyal Türü: Artigo
Dil:Inglês
Baskı/Yayın Bilgisi: National Academy of Sciences 2007
Konular:
Online Erişim:https://ncbi.nlm.nih.gov/pmc/articles/PMC1851576/
https://ncbi.nlm.nih.gov/pubmed/17389393
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.0701249104
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