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Cryptic proteolytic activity of dihydrolipoamide dehydrogenase
The mitochondrial enzyme, dihydrolipoamide dehydrogenase (DLD), is essential for energy metabolism across eukaryotes. Here, conditions known to destabilize the DLD homodimer enabled the mouse, pig, or human enzyme to function as a protease. A catalytic dyad (S456–E431) buried at the homodimer interf...
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| Hlavní autoři: | , , , |
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| Médium: | Artigo |
| Jazyk: | Inglês |
| Vydáno: |
National Academy of Sciences
2007
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| Témata: | |
| On-line přístup: | https://ncbi.nlm.nih.gov/pmc/articles/PMC1851069/ https://ncbi.nlm.nih.gov/pubmed/17404228 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.0610618104 |
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