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Mutations in the Dimer Interface of Dihydrolipoamide Dehydrogenase Promote Site-specific Oxidative Damages in Yeast and Human Cells

Dihydrolipoamide dehydrogenase (DLD) is a multifunctional protein well characterized as the E3 component of the pyruvate dehydrogenase and α-ketoglutarate dehydrogenase complexes. Previously, conditions predicted to destabilize the DLD dimer revealed that DLD could also function as a diaphorase and...

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Wedi'i Gadw mewn:
Manylion Llyfryddiaeth
Prif Awduron: Vaubel, Rachael A., Rustin, Pierre, Isaya, Grazia
Fformat: Artigo
Iaith:Inglês
Cyhoeddwyd: American Society for Biochemistry and Molecular Biology 2011
Pynciau:
Mynediad Ar-lein:https://ncbi.nlm.nih.gov/pmc/articles/PMC3220568/
https://ncbi.nlm.nih.gov/pubmed/21930696
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M111.274415
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