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ATM deficiency impairs thymocyte maturation because of defective resolution of T cell receptor α locus coding end breaks
The ATM (ataxia telangiectasia mutated) protein plays a central role in sensing and responding to DNA double-strand breaks. Lymphoid cells are unique in undergoing physiologic double-strand breaks in the processes of Ig class switch recombination and T or B cell receptor V(D)J recombination, and a r...
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| Main Authors: | , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
National Academy of Sciences
2007
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC1851038/ https://ncbi.nlm.nih.gov/pubmed/17405860 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.0611222104 |
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