ATM deficiency impairs thymocyte maturation because of defective resolution of T cell receptor α locus coding end breaks

The ATM (ataxia telangiectasia mutated) protein plays a central role in sensing and responding to DNA double-strand breaks. Lymphoid cells are unique in undergoing physiologic double-strand breaks in the processes of Ig class switch recombination and T or B cell receptor V(D)J recombination, and a r...

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Hlavní autoři: Vacchio, Melanie S., Olaru, Alexandru, Livak, Ferenc, Hodes, Richard J.
Médium: Artigo
Jazyk:Inglês
Vydáno: National Academy of Sciences 2007
Témata:
Biological Sciences
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC1851038/
https://ncbi.nlm.nih.gov/pubmed/17405860
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.0611222104
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