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Inositol Hexakisphosphate Is Bound in the ADAR2 Core and Required for RNA Editing
We report the crystal structure of the catalytic domain of human ADAR2, an RNA editing enzyme, at 1.7 angstrom resolution. The structure reveals a zinc ion in the active site and suggests how the substrate adenosine is recognized. Unexpectedly, inositol hexakisphosphate (IP(6)) is buried within the...
में बचाया:
| मुख्य लेखकों: | , , , , , |
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| स्वरूप: | Artigo |
| भाषा: | Inglês |
| प्रकाशित: |
2005
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| विषय: | |
| ऑनलाइन पहुंच: | https://ncbi.nlm.nih.gov/pmc/articles/PMC1850959/ https://ncbi.nlm.nih.gov/pubmed/16141067 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1126/science.1113150 |
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